Ronald Koeman might not have all of his squad available just yet, but his first starting XI of pre-season has still thrown up some interesting choices.
Summer signing Michael Keane starts on the bench, with captain Phil Jagielka and Ashley Williams forming a central defensive partnership. Under 20 World Cup-winning duo Jonjoe Kenny and Callum Connolly play at right back and left back respectively.
Maarten Stekelenburg starts in goal after Joel Robles was left out of the travelling squad. Club record signing Jordan Pickford is still on holiday after playing for England's Under 21s at the recent European Championship.
James McCarthy, who has attracted interest from a number of Premier League clubs, starts in central midfield with Morgan Schneiderlin, while Klaassen occupies a more advanced position.
Lennon makes his return to action after overcoming a mental health issue. He is likely to start on the right flank, with Lookman on the left and Rooney central.